We think of mass spectrometry as the science and technology of ions. Our interests therefore involve construction of mass spectrometers, fundamental studies of ion reactions and collision processes and applications to medicine, biochemistry and organic chemistry. A central current interest is in ambient ionization and its application in imaging tumor margins, monitoring therapeutic drugs in biofluids, following embryological development, and identifying microorganisms. Each of these experiments involves minimal sample workup. Another strong interest is in preparative mass spectrometry, both by soft landing ions onto surfaces in vacuum to generate new materials and also by collecting the products of solution-phase reactions occurring in electrospray droplets. In situ analysis using miniature mass spectrometers coupled to ambient ion sources for environmental, public safety and other applications is of interest. So, too, is on-line reaction monitoring. Ion chemistry is astonishingly rich as exemplified by nitrogen atom insertion into n-alkanes, chirally selective amino acid clustering and C-C bond formation, all being studied at atmospheric pressure.
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News and Events
- 09/13/20158th CAID Workshop: Mass Spectrometry in the Clinic and Surgery
- 05/31/20152015 Astonites Gathering
- 04/30/2015Congratulations to Professor Cooks on his selection to the National Academy of Sciences
- 09/07/20147th CAID Workshop: Instrumentation for Forensics, Nanoscience and Pharmaceutical Science
- 06/18/2014The World's Most Influential Scientific Minds: 2014
- 02/20/2014Mass Spectrometric Synthesis in the Undergraduate Organic Lab
- 12/01/2013Congratulations to our 2013 Student Award Recipients!
- 09/22/2013Intensive Short Course on Mass Spectrometry for Undergraduates
- 09/15/2013International Mass Spectrometry School (IMSS)
- 07/03/2013Prof. R. Graham Cooks was announced as the 2013 winner of the Dreyfus Prize in the Chemical Sciences.
- 06/09/20132013 Astonites Gathering
- 04/26/2013The American Chemical Society (ACS) recognized the R. B. Wetherill Laboratory of Chemistry as a National Historic Chemical Landmark
- 01/01/2013CNN_CSI_DESI Video
- 03/03/2010ScienceLives article: The Man Behind the Technology of "CSI"
Latest Publications (view all)
Jjunju, F. P. M.; Maher, S.; Li, A.; Syed, S. U.; Smith, B.; Heeren, R. M. A.; Taylor, S.; Cooks, R. G. “Hand-Held Portable Desorption Atmospheric Pressure Chemical Ionization Ion Source for in Situ Analysis of Nitroaromatic Explosives.” Anal. Chem. 2015, 87, 10047-10055. DOI: 10.1021/acs.analchem.5b02684
Li, A.; Hollerbach, A.; Luo, Q.; Cooks, R. G. “On-Demand Ambient Ionization of Picoliter Samples Using Charge Pulses. ” Angew. Chem., Int. Ed. 2015, 54, 6893-6895. DOI: 10.1002/anie.201501895
A. K. Jarmusch,K. S. Kerian, V.Pirro, T. Peat, C. A. Thompson, J. A. Ramos-Vara, M. O. Childressc, R. G. Cooks “Characteristic lipid profiles of canine non-Hodgkin's lymphoma from surgical biopsy tissue sections and fine needle aspirate smears by desorption electrospray ionization – mass spectrometry” Analyst, 2015, 140, 6321-6329. DOI: 10.1039/C5AN00825E