Ambient mass spectrometry using desorption electrospray ionization (DESI): Instrumentation, mechanisms and applications in forensics, chemistry, and biology
Journal:
Journal of Mass Spectrometry
Year:
2005
Volume:
40(10)
Page Number (starting):
1261
Page Number (ending):
1275 Analytical characteristics of DESI are summarized. Examples of applications to small and large molecules, to in situ analysis, and to high-throughput analyses are presented. Evidence is provided for both a heterogeneous charge-transfer mechanism and a droplet pick-up mechanism of ionization. The speed, lack of the need for sample preparation, selectivity, and sensitivity of DESI are all demonstrated and discussed. Instrumentation is also discussed. Forensic applications as well as emerging areas of application including tissue imaging are given emphasis
Funding:
InProteo, LLC
Funding:
Office of Naval Research
Funding:
Prosalia, Inc.
Funding:
Thermo Electron Corporation
DOI link:
doi: 10.1002/jms.922