Synchronized Desorption Electrospray Ionization Mass Spectrometry

Authors: 
Guangming Huang, Guangtao Li, Jason Duncan, Zheng Ouyang, R. Graham Cooks
Journal: 
Angewandte Chemie International Edition
Year: 
2010
Volume: 
50(11)
Page Number (starting): 
2503
Page Number (ending): 
2506

Keywords:

  • desorption electrospray ionization;
  • in situ analysis;
  • mass spectrometry;
  • surface analysis;
  • trace analysis
Thumbnail image of graphical abstract

Well-orchestrated: A new mass spectrometry protocol (see picture) synchronizes microdroplet creation, nebulizing gas pulsing, and DAPI interface opening. A number of advances result: 100-fold improved detection limit, simultaneous positive and negative ion spectra, and decreased spray volumes in desorption electrospray ionization (DESI).

Funding: 
Office of Naval Research
publication_user_reference: 

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