- Miniaturization begins with existing lab-scale instrumentation and shrinks the individual components.
- Takes advantage of developments in technology to reduce the overall size without sacrificing performance.
- A Moore's Law like effect is evident and a series of increasingly small instruments has been built (mini10, mini11, etc.)
view video of a handheld mass spectrometer
- Liang Gao, Qingyu Song, Garth E. Patterson, R. Graham Cooks, and Zheng Ouyang, "Handheld Rectilinear Ion Trap Mass Spectrometer" , Analytical Chemistry , 2006 , 78(17) , 5994-6002, doi: 10.1021/ac061144k