Aston Labs

Professional Information

Honors and Awards

• 2007       M.G. Mellon Award in Analytical Chemistry
• 2006       Thomas W. Keough Graduate Scholar
• 2005       Merck Research Laboratories Fellowship in Analytical/Physical Chemistry
• 2002       Graduate Fellowship of Chinese Academy of Sciences
• 1999       Outstanding Graduate Award of Lanzhou University
• 1998       Baogang Undergraduate Fellowship
• 1998       Second Class Award of National Undergraduate Chemistry Experiment Competition

Research Interests

• Gas-phase ion chemistry including ion/ion reactions and ion/molecule reactions.
• Gas-phase activation and dissociation techniques.

Education

• 2006 Aug  Ph.D. in analytical chemistry, Purdue University, West Lafayette, IN 47907, under direction of Prof. Scott A. McLuckey
• 2002 Jul  M.S. in organic chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China, under direction of Prof. Xuchang He and Donglu Bai
• 1999 Jul  B.S. in chemistry, Lanzhou University, Lanzhou, Gansu Province, P.R. China

Publications (outside the group)

• H. Han, Y. Xia, M. Yang and S. A. McLuckey, “Rapidly Alternating Transmission Mode Electron Transfer Dissociation and Collisional Activation for the Characterization of Polypeptide Ions.”  Anal. Chem., 80 (2008), 3492 -3497.
• Y. Xia, H. Han and S. A. McLuckey,  “Activation of Intact Electron Transfer Products of Polypeptides and Proteins in Cation Transmission Mode  Ion/Ion Reactions.” Anal. Chem., 80 (2008), 1111-1117.
• Y. Xia, B.A. Thomson, and S.A. McLuckey "Bi-directional Ion Transfer between Quadrupole Arrays: MSn Ion/Ion Reaction Experiments on a Quadrupole/Time-of-Flight Tandem Mass Spectrometer", Anal.Chem., 79 (2007), 8199 – 8206.
• C.K. Barlow, B.D.M. Hodges, Y. Xia, R.A.J. O'Hair, and S.A. McLuckey "Gas-Phase Ion/Ion Reactions of Transition Metal Complex Cations with Multiply-Charged Oligodeoxynucleotide Anions", J. Am. Soc. Mass Spectrom., 19 (2008), 281-293.
• Y. Xia, H.P. Gunawardena, D.E. Erickson, and S. A. McLuckey "Effects of Cation Charge Site Identity and Position on Electron Transfer Dissociation of Polypeptide Cations", J. Am. Chem. Soc., 129 (2007), 12232-12243.
• H. Han, Y. Xia, S.A. McLuckey, "Ion Trap Collisional Activation of c and z• Ions Formed via Gas-Phase Ion/Ion Electron Transfer Dissociation.", J. Proteome. Res. 6 (2007), 3062-3069.
• Y. Xia, S.A. McLuckey, "Evolution of Instrumentation for the Study of Gas-Phase Ion/Ion Chemistry via Mass Spectrometry." J. Am. Soc. Mass Spectrom., 19 (2008), 173-189.
• H. Han, Y. Xia, S.A. McLuckey, "Beam-type Collisional Activation of Polypeptide Cations that Survive Ion/Ion Electron Transfer.", Rapid Commun. Mass Spectrom., 12 (2007) 1555-1622.
• H.P. Gunawardena, L. Gorenstein, D.E. Erickson, Y. Xia, S. A. McLuckey, "Electron Transfer Dissociation of Multiply Protonated and Fixed Charge Disulfide Linked Polypeptides.", Int. J. Mass Spectrom., 265 (2007) 130-138.
• X. Liang, H. Han, Y. Xia, S. A. McLuckey, "A Pulsed Triple Ionization Source for Sequential Ion/Ion Reactions in an Electrodynamic Ion Trap.", J. Am. Soc. Mass Spectrom., 18 (2007) 369-376.
• Y. Xia, P. Chrisman, S.J. Pitteri, D.E. Erickson, and Scott A. McLuckey "Ion/Molecule Reactions of Cation Radicals Formed from Protonated Polypeptides via Gas-Phase Ion/Ion Electron Transfer", J. Am. Chem. Soc., 128 (2006) 11792-11798.
• Y. Xia, P. Chrisman, D. Erickson, J. Liu, X. Liang, F.A. Londry, M. Yang, S.A. McLuckey "Implementation of Ion/Ion Reactions in a Quadrupole/Time-of-Flight Tandem Mass Spectrometer", Anal. Chem., 78 (2006) 4146-4154.
• X. Liang, Y. Xia, S.A. McLuckey, "Alternately Pulsed Nano-electrospray Ionization/Atmospheric Pressure Chemical Ionization for Ion/Ion Reactions in an Electrodynamic Ion Trap.", Anal. Chem., 78 (2006) 3208-3212.
• Y. Xia, X. Liang, S.A. McLuckey "Ion-Trap vs. Low Energy Beam-Type Collision-Induced Dissociation of Protonated Ubiquitin Ions.", Anal. Chem. 78 (2006) 1218-1227.
• Y. Xia, X. Liang, S.A. McLuckey "Pulsed Dual Electrospray Ionization for Ion/Ion Reactions.", J. Am. Soc. Mass Spectrom. 16 (2005) 1750-1756.
• Y. Xia, X. Liang, S.A. McLuckey "Sonic Spray as a Dual Polarity Ion Source for Ion/Ion Reactions.", Anal. Chem. 77 (2005) 3683-3689.
• Y. Xia, J. Wu, F.A. Londry, J.W. Hager, S.A. McLuckey "Mutual Storage Mode Ion/Ion Reaction in a Hybrid Linear Ion Trap.", J. Am. Soc. Mass Spectrom., 16 (2005), 71-81.
• J. Wu, J.W. Hager, Y. Xia, F.A. Londry, S.A. McLuckey "Positive Ion Transmission Mode Ion/Ion Reactions in a Hybrid Linear Ion Trap.", Anal. Chem., 76 (2004), 5006-5015.
• P. Pan, H.P. Gunawardena, Y. Xia, S.A. McLuckey "Nano-Electrospray Ionization of Protein Mixtures: Solution pH and Protein pI.", Anal. Chem., 76 (2004), 1165-1174.