• Miniature Mass Spectrometer

    Miniature Mass Spectrometer

  • Aston Labs - 2015

    Aston Labs - 2015

  • DESI_MS Imaging for Cancer Diagnosis

    DESI_MS Imaging for Cancer Diagnosis



We think of mass spectrometry as the science and technology of ions. Our interests therefore involve construction of mass spectrometers, fundamental studies of ion reactions and collision processes and applications to medicine, biochemistry and organic chemistry. A central current interest is in ambient ionization and its application in imaging tumor margins, monitoring therapeutic drugs in biofluids, following embryological development, and identifying microorganisms. Each of these experiments involves minimal sample workup. Another strong interest is in preparative mass spectrometry, both by soft landing ions onto surfaces in vacuum to generate new materials and also by collecting the products of solution-phase reactions occurring in electrospray droplets. In situ analysis using miniature mass spectrometers coupled to ambient ion sources for environmental, public safety and other applications is of interest. So, too, is on-line reaction monitoring. Ion chemistry is astonishingly rich as exemplified by nitrogen atom insertion into n-alkanes, chirally selective amino acid clustering and C-C bond formation, all being studied at atmospheric pressure.

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Fundamentals / Concepts



 Concepts  Instrumentation  Applications

Latest Publications (view all)

Jjunju, F. P. M.; Maher, S.; Li, A.; Syed, S. U.; Smith, B.; Heeren, R. M. A.; Taylor, S.; Cooks, R. G. “Hand-Held Portable Desorption Atmospheric Pressure Chemical Ionization Ion Source for in Situ Analysis of Nitroaromatic Explosives.” Anal. Chem. 2015, 87, 10047-10055. DOI: 10.1021/acs.analchem.5b02684

Li, A.; Hollerbach, A.; Luo, Q.; Cooks, R. G. “On-Demand Ambient Ionization of Picoliter Samples Using Charge Pulses. ” Angew. Chem., Int. Ed. 2015, 54, 6893-6895. DOI: 10.1002/anie.201501895

A. K. Jarmusch,K. S. Kerian, V.Pirro, T. Peat, C. A. Thompson, J. A. Ramos-Vara, M. O. Childressc, R. G. Cooks “Characteristic lipid profiles of canine non-Hodgkin's lymphoma from surgical biopsy tissue sections and fine needle aspirate smears by desorption electrospray ionization – mass spectrometry” Analyst, 2015, 140, 6321-6329. DOI: 10.1039/C5AN00825E

On the Cover (view all)

Angewandte Chemie