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  • Aston Labs - 2019


We think of mass spectrometry as the science and technology of ions. Our interests therefore involve construction of mass spectrometers, fundamental studies of ion reactions and collision processes and applications to medicine, biochemistry and organic chemistry. A central current interest is in ambient ionization and its application in imaging tumor margins, monitoring therapeutic drugs in biofluids, following embryological development, and identifying microorganisms. Each of these experiments involves minimal sample workup. Another strong interest is in preparative mass spectrometry, both by soft landing ions onto surfaces in vacuum to generate new materials and also by collecting the products of solution-phase reactions occurring in electrospray droplets. In situ analysis using miniature mass spectrometers coupled to ambient ion sources for environmental, public safety and other applications is of interest. So, too, is on-line reaction monitoring. Ion chemistry is astonishingly rich as exemplified by nitrogen atom insertion into n-alkanes, chirally selective amino acid clustering and C-C bond formation, all being studied at atmospheric pressure.

Check out the Cooks Group Research Poster

Latest Publications (view all)

Brett M. Marsh, Saquib Rahman, Victoria M. Benkowski, Shane Tichy, and R. Graham Cooks “Space Charge Compensation in Air by Counterion Flow in 3D Printed Electrode Structure” Int. J. Mass Spectrom. (2021)

Nicolás M. Morato, R. Graham Cooks “Inter-platform assessment of performance of high-throughputdesorption electrospray ionization mass spectrometry” Talanta Open (2021)

Zhuoer Xie, Christina R. Ferreira, Alessandra A. Virequ, and R. Graham Cooks “Multiple Reaction Monitoring Profiling (MRM Profiling): Small Molecule Exploratory Analysis Guided by Chemical Functionality” Chem. Phys. Lipids (2021)

On the Cover (view all)

JASMS June 2017