2020-2024
Kai-Hung Huang, Zhenwei Wei, and R. Graham Cooks “Accelerated Reactions of Amines with Carbon Dioxide Driven by Superacid at the Microdroplet Interface” Chem. Sci. (2020) DOI: 10.1039/D0SC05625A
Rong Chen, Zhenwei Wei, and R. Graham Cooks “Collection and Characterization by Mass Spectrometry of the Neutral Serine Octamer Generated upon Sublimation” Anal. Chem. (2020) DOI: 10.1021/acs.analchem.0c04107
H. Samuel Ewan, Shruti A. Biyana, Jaycie DiDomenico, David Logsdon, Tiago J.P. Sobreira, Larisa Avramova, and R. Graham Cooks “Aldol Reactions of Biorenewable Triacetic Acid Lactone Precursor Evaluated Using Desorption Electrospray Ionization Mass Spectrometry High-Throughput Experimentation and Validated by Continuous Flow Synthesis” ACS Comb. Sci. (2020) DOI: 10.1021/acscombsci.0c00119
Madison E. Edwards, Thomas De Luca, Christina Ferreira, Kimberly S. Collins, Eric A. Benson, Tiago J.P. Sobreira, and R. Graham Cooks “Multiple reaction monitoring profiling as an analytical strategy to investigate lipids in extracellular vesicles” J. Mass. Spectrom. (2020) DOI: 10.1002/jms.4681
Yangjie Li, Tsdale Mehari, Zhenwei Wei, Yong Liu, and R. Graham Cooks “Reaction Acceleration at Solid/Solution Interfaces: Katritzky Reaction Catalyzed by Glass Particles” Angew. Chem. Int. Ed. (2020) DOI: 10.1002/anie.202014613
David L. Logsdon, Yangjie Li, Tiago J. P. Sobreira, Christina R. Ferreira, David H. Thompson, and R. Graham Cooks “High Throughput Screening of Reductive Amination Reactions using Desorption Electrospray Ionization (DESI) Mass Spectrometry” Org. Process Res. Dev. (2020) DOI: 10.1021/acs.oprd.0c00230
Nicolás M. Morato, Dylan T. Holden, and R. Graham Cooks “High Throughput Label-Free Enzymatic Assays using Desportion Electrospray Ionization Mass Spectrometry” Angew. Chem. Int. Ed. (2020) DOI: 10.1002/anie.202009598
Pallab Basuri, L. Edwin Gonzalez, Nicolas M. Morato, Thalappil Pradeep, and R. Graham Cooks “Accelerated Microdoplet Synthesis of Benzimidazoles by Nucleopilic Addition to Protonated Carboxylic Acids” Chem. Sci. (2020) DOI: 10.1039/D0SC02467H
Robert L. Schrader, Brett M. Marsh, and R. Graham Cooks “Temporal distribution of ions in ambient pressure drift tubes with turns” IJMS (2020) DOI: 10.1016/j.ijms.2020.116391
Yangjie Li, Yanyang Hu, David L. Logsdon, Yong Liu, Yuejie Zhao, and R. Graham Cooks “Accelerated Forced Degradation of Theraputic Peptides in Levitated Micrdoplets” Pharmaceutical Research (2020) DOI: 10.1007/s11095-020-02868-y
Tiago J. P. Sobreira, Larisa Avramova, Botond Szilagyi, David L. Logsdon, Bradley P. Loren, Zinia Jaman, Ryan T. Hilger, Richard S. Hosler, Christiana R. Ferreira, Andy Koswara, David H. Thompson, R. Graham Cooks, and Zoltan K. Nagy “High-throughput screening of organic reactions in microdroplets using desorption electrospray ionzation mass spectrometry (DESI-MS): hardware and software implementation” Anal. Meth. (2020) DOI: 10.1039/D0AY00072H
Lucas J. Szalwinski, Dylan T. Holden, Nicolás M. Morato, and R. Graham Cooks “2D MS/MS Spectra Recorded in the Time Domain using Repettitive Frequency Sweeps in Linear Quadrupole Ion Traps” Anal. Chem (2020) DOI: 10.1021/acs.analchem.0c01719
Yangjie Li, Tsdale F. Mehari, Zhenwei Wei, Yong Liu, and R. Graham Cooks “Reaction Acceleration at Air-Solution Interfaces: Anisotropic Rate Constants for Katritzky Transamination” J. Mass. Spectrom. (2020) DOI: 10.1002/jms.4585
Namita Narendra, Xingshuo Chen, Jinyin Wang, James Charles, R. Graham Cooks, and Tillmann Kubis “Quantum Mechanical Modeling of Reaction Rate Acceleration in Microdroplets” J. Phys. Chem. A (2020) DOI: 10.1021/acs.jpca.0c03225
Zhenwei Wei, Yangjie Li, R. Graham Cooks, and Xin Yan “Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments” Ann. Rev. Phys. Chem. (2020) DOI: 10.1146/annurev-physchem-121319-110654
Lucas J. Szalwinski, Dalton T. Snyder, Mitch Wells, and R. Graham Cooks “Triple Resonance Methods to Improve Performance of Ion Trap Precursor and Neutral Loss Scans” J. Am. Soc. Mass Spectrom. (2020) DOI: 10.1021/jasms.0c00048
Nicolás M. Morato and R. Graham Cooks “Cutting-edge developments in mass spectrometry: A hands-on workshops” Int. J. Mass Spectrom. (2020) DOI: 10.1016/j.ijms.2020.116337
Patrick W. Fedick, Nicolás M. Morato, Fan Pu, and R. Graham Cooks “Raman spectroscopy coupled with ambient ionization mass spectrometry: A forensic laboratory investigation into rapid and simple dual instrumental analysis techniques” Int. J. Mass Spectrom. (2020) DOI: 10.1016/j.ijms.2020.116326
Zinia Jaman, David L. Logsdon, Botond Szilágyi, Tiago J. P. Sobreira, Deborah Aremu, Larisa Avramova, R. Graham Cooks, and David H. Thompson “High-Throughput Experimentation and Continuous Flow Evaluation of Nucleophilic Aromatic Substitution Reactions” ACS Comb. Sci. (2020) DOI: 10.1021/acscombsci.9b00212
Robert L. Schrader, Brett M. Marsh, and R. Graham Cooks “Fourier Transform Ion Mobility Linear Ion Trap Mass Spectrometer using Frequency Encoding for Recognition of Related Compounds in a Single Acquisition” Anal. Chem. (2020) DOI: 10.1021/acs.analchem.9b05507
Patrick W. Fedick, Fan Pu, Nicolas M. Morato, and R. Graham Cooks “Identification and Confirmation of Fentanyls on Paper using Portable Surface Enhanced Raman Spectroscopy and Paper Spray Ionization Mass Spectrometry” J. Am. Soc. Mass Spectrom. (2020) DOI: 10.1021/jasms.0c00004
Honggang Nie, Zhenwei Wei, Lingqi Qiu, Xingshuo Chen, Dylan T. Holden, and R. Graham Cooks “High-yield gram-scale organic synthesis using accelerated microdroplet/thin film reactions with solvent recycling” Chem. Sci. (2020) DOI: 10.1039/C9SC06265C
Fernanda Bertuccez Cordeiro, Alan K. Jarmusch, Marisol León, Christina R. Ferreira, Valentina Pirro, Livia S. Eberlin, Judy Hallett, Maria Angelica Miglino, and R. Graham Cooks “Mammalian ovarian lipid distributions by desorption electrospray ionization—mass spectrometry (DESI-MS) imaging” Anal. Bioanal. Chem. (2020) DOI: 10.1007/s00216-019-02352-6
Fan Pu, Sangeeta Pandey, Lane R. Bushman, Peter L. Anderson, Zheng Ouyang, and R. Graham Cooks “Direct quantitation of tenofovir diphosphase in human blood with mass spectrometry for adherence monitoring” Anal. Bioanal. Chem. (2020) DOI: 10.1007/s00216-019-02304-0
Christina R. Ferreira, Alan K. Jarmusch, Clint M. Alfaro, and R. Graham Cooks “Ambient Lipidomic Analysis of Single Mammalian Oocytes and Preimplantation Embyros Using Desorption Electrospray Ionization (DESI) Mass Spectrometry.” in Single Cell Metabolism: Methods and Protocols (2020) DOI: 10.1007/978-1-4939-9831-9_13
Meng Wang, Xiao-Fei Gao, Rui Su, Peng He, Yuan-Yuan Cheng, Ke Li, Dongbo Mi, Xiaoping Zhang, Xinglei Zhang, Huanwen Chen, and R. Graham Cooks "Abundant Production of Reactive Water Radical Cations under Ambient Conditions" CCS Chem (2021) DOI:10.31635/ccschem.021.202101427
Kai-Hung Huang, Jyotirmoy Ghosh, Shiqing Xu, and R. Graham Cooks "Late-Stage Functionalization and Characterization of Drugs by High-Throughput Desorption Electrospray Ionization Mass Spectrometry" ChemPlusChem (2021) DOI:10.1002/cplu.202100449
L. Edwin Gonzalez, Lucas J. Szalwinski, Brett M. Marsh, J. Mitchell Wells, and R. Graham Cooks “Immediate and sensitive detection of sporulated Bacillus subtilis by microwave release and tandem mass spectrometry of dipicolinic acid” Analyst (2021) DOI:10.1039/D1AN01796A
Nicolás M. Morato, MyPhuong T. Le, Dylan T. Holden, and R. Graham Cooks “Automated High-Throughput System Combining Small-Scale Synthesis with Bioassays and Reaction Screening” SLAS Technology (2021) DOI:10.1177/24726303211047839
Lucas J. Szalwinski, Yanyang Hu, Nicolás M. Morato, R. Graham Cooks, and Gert IJ. Salentijn “Novel Ion Trap Scan Modes to Develop Criteria for On-Site Detection of Sulfonamide Antibiotics” Anal. Chem. (2021) DOI:10.1021/acs.analchem.1c02790
Lingqi Qiu, Zhenwei Wei, Honggang Nie, R. Graham Cooks “Reaction Acceleration Promoted by Partial Solvation at the Gas/Solution Interface” ChemPlusChem (2021)DOI: 10.1002/cplu.202100373
Rong Chen, Hannah Marie Brown and R. Graham Cooks “Metabolic profiles of human brain parenchyma and glioma for rapid tissue diagnosis by targeted desorption electrospray ionization mass spectrometry ”Anal. Bioanal. Chem. (2021)DOI: 10.1007/s00216-021-03593-0
MyPhuong T. Le, Nicolás M. Morato, Andreas Kaerner, Christopher J. Welch, and R. Graham Cooks “Fragmentation of Polyfunctional Compounds Recorded Using Automated High-Throughput Desorption Electrospray Ionization” J. Am. Soc. Mass Spectrom. (2021) DOI: 10.1021/jasms.1c00176
Robert L. Schrader, Brett M. Marsh, and R. Graham Cooks “Atmospheric Pressure Drift Tube Ion Mobility Spectrometry Coupled with Two-Dimensional Tandem Mass Spectrometry” J. Am. Soc. Mass Spectrom. (2021) DOI: 10.1021/jasms.1c00180
Madison E. Edwards, César A. Marasco Jr, Tracey B. Schock, Tiago J.P. Sobreira, Christina R. Ferreira, R. Graham Cooks “Exploratory analysis using MRM profiling mass spectrometry of a candidate metabolomics sample for testing system suitability” Int. J. Mass Spectrom. (2021) DOI: 10.1016/j.ijms.2021.116663
Yangjie Li, Kai-Hung Huang, Nicolás M. Morato and R. Graham Cooks “Glass surface as strong base, ‘green’ heterogeneous catalyst and degradation reagent” Chem. Sci. (2021) DOI: 10.1039/D1SC02708E
Brett M. Marsh, Saquib Rahman, Victoria M. Benkowski, Shane Tichy, and R. Graham Cooks “Space Charge Compensation in Air by Counterion Flow in 3D Printed Electrode Structure” Int. J. Mass Spectrom. (2021) DOI: 10.1016/j.ijms.2021.116637
Nicolás M.Morato, R. Graham Cooks “Inter-platform assessment of performance of high-throughputdesorption electrospray ionization mass spectrometry” Talanta Open (2021) DOI: 10.1016/j.talo.2021.100046
Zhuoer Xie, Christina R. Ferreira, Alessandra A. Virequ, and R. Graham Cooks “Multiple Reaction Monitoring Profiling (MRM Profiling): Small Molecule Exploratory Analysis Guided by Chemical Functionality” Chemistry and Physics of Lipids (2021) DOI: 10.1016/j.chemphyslip.2021.105048
Hannah Marie Brown, Clint M. Alfaro, Valentina Pirro, Mahua Dey, Eyas M. Hattab, Aaron A. Cohen-Gadol, and R. Graham Cooks “Intraoperative Mass Spectrometry Platform for IDH Mutation Status Prediction, Glioma Diagnosis, and Estimation of Tumor Cell Infiltration” Journal of Applied Laboratory Medicine (2021) DOI: 10.1093/jalm/jfaa233
Lucas J. Szalwinski and R. Graham Cooks “Complex Mixture Analysis by Two-Dimensional Mass Spectrometry using a Miniature Ion Trap” Talanta Open (2021) DOI: 10.1016/j.talo.2020.100028
L. Edwin Gonzalez, Lucas J. Szalwinski, Thomas C. Sams, Eric T. Dziekonski, and R. Graham Cooks "Metabolomic and Lipidomic Profiling of Bacillus Using Two-Dimensional Tandem Mass Spectrometry" Anal. Chem. (2022) DOI:10.1021/acs.analchem.2c03961
Nicolás M. Morato, Hannah Marie Brown, Diogo Garcia, Erik H. Middlebrooks, Mark Jentoft, Kaisorn Chaichana, Alfredo Quiñones-Hinojosa, and R. Graham Cooks "High-throughput analysis of tissue microarrays using automated desorption electrospray ionization mass spectrometry" Sci. Rep. (2022) DOI:10.1038/s41598-022-22924-4
Jyotirmoy Ghosh, Joshua Mendoza, and R Graham Cooks "Accelerated and Concerted Aza-Michael Addition and SuFEx Reaction in Microdroplets in Unitary and High-Throughput Formats" Angew. Chem. (2022) DOI:10.1002/anie.202214090
Dylan T Holden, Nicolás M Morato, and R. Graham Cooks "Aqueous microdroplets enable abiotic synthesis and chain extension of unique peptide isomers from free amino acids" Proc. Natl. Acad. Sci. U.S.A. (2022) DOI: 10.1073/pnas.2212642119
Jyotirmoy Ghosh and R. Graham Cooks "Facile Synthesis of Triazoles using Electrospray-Deposited Copper Nanomaterials to Catalyze Azide-Alkyne Cycloaddition (AAC) Click Reactions" ChemPlusChem (2022) DOI:10.1002/cplu.202200252
Lingqi Qiu and R. Graham Cooks "Simultaneous and Spontaneous Oxidation and Reduction in Microdroplets by the Water Radical Cation/Anion Pair" Angew. Chem. (2022) DOI:10.1002/anie.202210765
Lingqi Qiu, Nicolás M Morato, Kai-Hung Huang, and R. Graham Cooks "Spontaneous Water Radical Cation Oxidation at Double Bonds in Microdroplets" Front. Chem. (2022) DOI:10.3389/fchem.2022.903774
Lingqi Qiu, Michael D. Psimos, and R. Graham Cooks "Spontaneous Oxidation of Aromatic Sulfones to Sulfonic Acids in Microdroplets" JASMS (2022) DOI:10.1021/jasms.2c00029
Sangeeta Pandey, Yanyang Hu, Lane R. Bushman, Jose Castillo‑Mancilla, Peter L. Anderson, and R. Graham Cooks "Miniature mass spectrometer–based point‑of‑care assay for cabotegravir and rilpivirine in whole blood" Anal. Bioanal. Chem. (2022) DOI:10.1007/s00216-022-03954-3
Lucas Szalwinski, L. Edwin Gonzalez, Nicolás M Morato, Brett Marsch, and R. Graham Cooks"Bacterial Growth Monitored by Two-Dimensional Tandem Mass Spectrometry" Analyst (2022) DOI:10.1039/D1AN01901E
Xingshuo Chen, Zhenwei Wei, Kai-Hung Huang, Mycah Uehling, Michael Wleklinski, Shane Krska, Alexey A. Makarov, Timothy Nowak, and R Graham Cooks "Pd Reaction Intermediates in Suzuki-Miyaura Cross-coupling Characterized by Mass Spectrometry" ChemPlusChem (2022) DOI:10.1002/cplu.202100545
Samadhi C. Kulathunga, Nicolás M. Morato, Qing Zhou, R. Graham Cooks and, Andrew D. Mesecar "Desorption Electrospray Ionization Mass Spectrometry Assay for Label-Free Characterization of SULT2B1b Enzyme Kinetics" ChemMedChem (2022) DOI:10.1002/cmdc.202200043
MyPhuong T. Le, Dylan T. Holden, Jeremy M. Manheim, Eric T. Dziekonski, Kiran Iyer, R. Graham Cooks "Two-dimensional Tandem Mass Spectrometry for Biopolymer Structural Analysis" Angewandte Chemie (2023) DOI:10.1002/ange.202315904
Yanyang Hu, Eric T. Dziekonski, Donna M. Wang, L. Edwin Gonzalez, R. Graham Cooks "Rapid Identification of Phenolics in Mixtures by Two-Dimensional Tandem Mass Spectrometry with Microdroplet Accelerated Derivatization Reactions" Analysis & Sensing (2023) DOI:10.1002/anse.202300081
L. Edwin Gonzalez, Dalton T. Snyder, Harman Casey, Yanyang Hu, Donna M. Wang, Megan Guetzloff, Nicole Huckaby, Eric T. Dziekonski, J. Mitchell Wells, and R. Graham Cooks "Machine-Learning Classification of Bacteria Using Two-Dimensional Tandem Mass Spectrometry" Anal. Chem. (2023) DOI:10.1021/acs.analchem.3c04016
Lingqi Qiu, Mousumi Saha, Stefan Kraft, Eric T. Dziekonski, Christopher J. Welch, Yumin Dai, Andreas Kaerner, R. Graham Cooks "Quantitative Determination of Water in Organic Liquids by Ambient Mass Spectrometry" Angew. Chem. Int. Ed. (2023) DOI:10.1002/ange.202310884
Nicolás M. Morato and R. Graham Cooks "Desorption Electrospray Ionization Mass Spectrometry: 20 Years" Acc. Chem. Res. (2023) DOI:10.1021/acs.accounts.3c00382
Eric T. Dziekonski, Gregory S. Eakins, R. Graham Cooks "Enabling one- and two-dimensional mass spectrometry in a linear quadrupole ion trap" Int J Mass Spectrom (2023) DOI:10.1016/j.ijms.2023.117099
R. Graham Cooks "Ion traps and Piero Traldi: A brief appreciation" Mass. Spectrom. Rev. (2023) DOI:10.1002/mas.21753
Kai-Hung Huang, Nicolás M. Morato, Yunfei Feng, R. Graham Cooks "High-throughput Diversification of Complex Bioactive Molecules by Accelerated Synthesis in Microdroplets" Angew. Chem. Int. Ed. (2023) DOI:10.1002/anie.202300956
R. Graham Cooks, Yunfei Feng, Kai-Hung Huang, Nicolás M. Morato, Lingqi Qiu "Re-Imagining Drug Discovery using Mass Spectrometry" Isr. J. Chem. (2023) DOI:10.1002/ijch.202300034 [pdf]
Eric T. Dziekonski, Thomas C. Sams, Lucas J. Szalwinski, L. Edwin Gonzalez, R. Graham Cooks "Automated desorption electrospray ionization two-dimensional tandem mass spectrometry: Instrumentation and software for high throughput analysis" Int J Mass Spectrom (2023) DOI:10.1016/j.ijms.2023.117023
Sangeeta Pandey, Yanyang Hu, Peter L. Anderson, Jennifer J. Kiser, R. Graham Cooks "Miniature mass spectrometer-based point-of-care assay for measuring phosphatidylethanol in blood" Analyst (2023) DOI:10.1039/D3AN00098B
Jyotirmoy Ghosh, R. Graham Cooks "Mass spectrometry in materials synthesis" Trends in Analytical Chemistry (2023) DOI:10.1016/j.trac.2023.117010
Lingqi Qiu, R. Graham Cooks "Oxazolone mediated peptide chain extension and homochirality in aqueous microdroplets" Proc. Natl. Acad. Sci. (2024) DOI:10.1073/pnas.2309360120
Lingqi Qiu, R. Graham Cooks "Spontaneous Oxidation in Aqueous Microdroplets: Water Radical Cation as Primary Oxidizing Agent" Angew. Chem. Int. Ed. (2024) DOI:10.1002/ange.202400118
Lingqi Qiu, R. Graham Cooks "Pitfalls in Using Isotopic Distributions for Structural Interpretation by Mass Spectrometry" J. Am. Soc. Mass Spectrom. (2024) DOI:10.1021/jasms.3c00457
Wei Hua, Wenpeng Zhang, Hannah Brown, Junhan Wu, Xinqi Fang, Mahdiyeh Shahi, Rong Chen, Haoyue Zhang, Bin Jiao, Nan Wang, Hao Xu, Minjie Fu, Xiaowen Wang, Jinsen Zhang, Xin Zhang, Qijun Wang, Wei Zhu, Dan Ye, Diogo Moniz Garcia, Kaisorn Chaichana, R. Graham Cooks, Zheng Ouyang, Ying Mao, Alfredo Quinones-Hinojosa "Rapid detection of IDH mutations in gliomas by intraoperative mass spectrometry" Proc. Natl. Acad. Sci. (2024) DOI:10.1073/pnas.2318843121
R. Graham Cooks, Dylan T. Holden "Breaking down microdroplet chemistry" Science (2024) DOI:10.1126/science.adp7627
Yunfei Feng, Nicolás M. Morato, Kai-Hung Huang, Mina Lin and R. Graham Cooks, “High-Throughput Label-Free Opioid Receptor Binding Assays using an Automated Desorption Electrospray Ionization Mass Spectrometry Platform” Chem. Comm. (2024) DOI:10.1039/D4CC02346C
Lingqi Qiu, Xilai Li, Dylan T. Holden and R. Graham Cooks, “Reaction Acceleration at a Levitated Droplet Surface by Vapor Dosing from a Partner Droplet” Chem. Sci. (2024) DOI:10.1039/D4SC03528C
Jie Li, Nicolás M. Morato, Lori S. Westover, Pravien Abeywickrema, Jieping Geng, Madison Piassek, David Harden, Iulia Strambeanu, Zhicai Shi, R. Graham Cooks, Juncai Meng. "High-Throughput Assessment of Bile Salt Export Pump Inhibition Using RapidFire-MS and DESI-MS" ACS Med Chem Lett. (2024) DOI:10.1021/acsmedchemlett.4c00302
Mahdiyeh Shahi, Steve Pringle, Michael Morris, Diogo M. Garcia, Alfredo Quiñones-Hinojosa, R. Graham Cooks. "Detection of IDH mutation in glioma by desorption electrospray ionization (DESI) tandem mass spectrometry" Sci Rep. (2024) DOI:10.1038/s41598-024-77044-y
Kai-Hung Huang, Nicolás M. Morato, Yunfei Feng, Alexis Toney, R. Graham Cooks. "Rapid Exploration of Chemical Space by High-throughput Desorption Electrospray Ionization Mass Spectrometry" J. Am. Chem. Soc. (2024) DOI:10.1021/jacs.4c11037
Mousumi Saha, Lingqi Qiu, Yu Han-Hallett, Christopher J. Welch, R. Graham Cooks. "Simultaneous Quantitation of Multiple Biological Thiols Using Reactive Ionization and Derivatization with Charged Mass Tags". Anal. Chem. (2024) DOI: 10.1021/acs.analchem.4c03807 PDF Reprint