Kai-Hung Huang, Zhenwei Wei, and R. Graham Cooks “Accelerated Reactions of Amines with Carbon Dioxide Driven by Superacid at the Microdroplet Interface” Chem. Sci. (2020) DOI: 10.1039/D0SC05625A

Rong Chen, Zhenwei Wei, and R. Graham Cooks “Collection and Characterization by Mass Spectrometry of the Neutral Serine Octamer Generated upon Sublimation” Anal. Chem. (2020) DOI: 10.1021/acs.analchem.0c04107

H. Samuel Ewan, Shruti A. Biyana, Jaycie DiDomenico, David Logsdon, Tiago J.P. Sobreira, Larisa Avramova, and R. Graham Cooks “Aldol Reactions of Biorenewable Triacetic Acid Lactone Precursor Evaluated Using Desorption Electrospray Ionization Mass Spectrometry High-Throughput Experimentation and Validated by Continuous Flow Synthesis” ACS Comb. Sci. (2020) DOI: 10.1021/acscombsci.0c00119

Madison E. Edwards, Thomas De Luca, Christina Ferreira, Kimberly S. Collins, Eric A. Benson, Tiago J.P. Sobreira, and R. Graham Cooks “Multiple reaction monitoring profiling as an analytical strategy to investigate lipids in extracellular vesicles” J. Mass. Spectrom. (2020) DOI: 10.1002/jms.4681

Yangjie Li, Tsdale Mehari, Zhenwei Wei, Yong Liu, and R. Graham Cooks “Reaction Acceleration at Solid/Solution Interfaces: Katritzky Reaction Catalyzed by Glass Particles” Angew. Chem. Int. Ed. (2020) DOI: 10.1002/anie.202014613

David L. Logsdon, Yangjie Li, Tiago J. P. Sobreira, Christina R. Ferreira, David H. Thompson, and R. Graham Cooks “High Throughput Screening of Reductive Amination Reactions using Desorption Electrospray Ionization (DESI) Mass Spectrometry” Org. Process Res. Dev. (2020) DOI: 10.1021/acs.oprd.0c00230

Nicolás M. Morato, Dylan T. Holden, and R. Graham Cooks “High Throughput Label-Free Enzymatic Assays using Desportion Electrospray Ionization Mass Spectrometry” Angew. Chem. Int. Ed. (2020) DOI: 10.1002/anie.202009598

Pallab Basuri, L. Edwin Gonzalez, Nicolas M. Morato, Thalappil Pradeep, and R. Graham Cooks “Accelerated Microdoplet Synthesis of Benzimidazoles by Nucleopilic Addition to Protonated Carboxylic Acids” Chem. Sci. (2020) DOI: 10.1039/D0SC02467H

Robert L. Schrader, Brett M. Marsh, and R. Graham Cooks “Temporal distribution of ions in ambient pressure drift tubes with turns” IJMS (2020) DOI: 10.1016/j.ijms.2020.116391

Yangjie Li, Yanyang Hu, David L. Logsdon, Yong Liu, Yuejie Zhao, and R. Graham Cooks “Accelerated Forced Degradation of Theraputic Peptides in Levitated Micrdoplets” Pharmaceutical Research (2020) DOI: 10.1007/s11095-020-02868-y

Tiago J. P. Sobreira, Larisa Avramova, Botond Szilagyi, David L. Logsdon, Bradley P. Loren, Zinia Jaman, Ryan T. Hilger, Richard S. Hosler, Christiana R. Ferreira, Andy Koswara, David H. Thompson, R. Graham Cooks, and Zoltan K. Nagy “High-throughput screening of organic reactions in microdroplets using desorption electrospray ionzation mass spectrometry (DESI-MS): hardware and software implementation” Anal. Meth. (2020) DOI: 10.1039/D0AY00072H

Lucas J. Szalwinski, Dylan T. Holden, Nicolás M. Morato, and R. Graham Cooks “2D MS/MS Spectra Recorded in the Time Domain using Repettitive Frequency Sweeps in Linear Quadrupole Ion Traps” Anal. Chem (2020) DOI: 10.1021/acs.analchem.0c01719

Yangjie Li, Tsdale F. Mehari, Zhenwei Wei, Yong Liu, and R. Graham Cooks “Reaction Acceleration at Air-Solution Interfaces: Anisotropic Rate Constants for Katritzky Transamination” J. Mass. Spectrom. (2020) DOI: 10.1002/jms.4585

Namita Narendra, Xingshuo Chen, Jinyin Wang, James Charles, R. Graham Cooks, and Tillmann Kubis “Quantum Mechanical Modeling of Reaction Rate Acceleration in Microdroplets” J. Phys. Chem. A (2020) DOI: 10.1021/acs.jpca.0c03225

Zhenwei Wei, Yangjie Li, R. Graham Cooks, and Xin Yan “Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments” Ann. Rev. Phys. Chem. (2020) DOI: 10.1146/annurev-physchem-121319-110654

Lucas J. Szalwinski, Dalton T. Snyder, Mitch Wells, and R. Graham Cooks “Triple Resonance Methods to Improve Performance of Ion Trap Precursor and Neutral Loss Scans” J. Am. Soc. Mass Spectrom. (2020) DOI: 10.1021/jasms.0c00048

Nicolás M. Morato and R. Graham Cooks “Cutting-edge developments in mass spectrometry: A hands-on workshops” Int. J. Mass Spectrom. (2020) DOI: 10.1016/j.ijms.2020.116337

Patrick W. Fedick, Nicolás M. Morato, Fan Pu, and R. Graham Cooks “Raman spectroscopy coupled with ambient ionization mass spectrometry: A forensic laboratory investigation into rapid and simple dual instrumental analysis techniques” Int. J. Mass Spectrom. (2020) DOI: 10.1016/j.ijms.2020.116326

Zinia Jaman, David L. Logsdon, Botond Szilágyi, Tiago J. P. Sobreira, Deborah Aremu, Larisa Avramova, R. Graham Cooks, and David H. Thompson “High-Throughput Experimentation and Continuous Flow Evaluation of Nucleophilic Aromatic Substitution Reactions” ACS Comb. Sci. (2020) DOI: 10.1021/acscombsci.9b00212

Robert L. Schrader, Brett M. Marsh, and R. Graham Cooks “Fourier Transform Ion Mobility Linear Ion Trap Mass Spectrometer using Frequency Encoding for Recognition of Related Compounds in a Single Acquisition” Anal. Chem. (2020) DOI: 10.1021/acs.analchem.9b05507

Patrick W. Fedick, Fan Pu, Nicolas M. Morato, and R. Graham Cooks “Identification and Confirmation of Fentanyls on Paper using Portable Surface Enhanced Raman Spectroscopy and Paper Spray Ionization Mass Spectrometry” J. Am. Soc. Mass Spectrom. (2020) DOI: 10.1021/jasms.0c00004

Honggang Nie, Zhenwei Wei, Lingqi Qiu, Xingshuo Chen, Dylan T. Holden, and R. Graham Cooks “High-yield gram-scale organic synthesis using accelerated microdroplet/thin film reactions with solvent recycling” Chem. Sci. (2020) DOI: 10.1039/C9SC06265C

Fernanda Bertuccez Cordeiro, Alan K. Jarmusch, Marisol León, Christina R. Ferreira, Valentina Pirro, Livia S. Eberlin, Judy Hallett, Maria Angelica Miglino, and R. Graham Cooks “Mammalian ovarian lipid distributions by desorption electrospray ionization—mass spectrometry (DESI-MS) imaging” Anal. Bioanal. Chem. (2020) DOI: 10.1007/s00216-019-02352-6

Fan Pu, Sangeeta Pandey, Lane R. Bushman, Peter L. Anderson, Zheng Ouyang, and R. Graham Cooks “Direct quantitation of tenofovir diphosphase in human blood with mass spectrometry for adherence monitoring” Anal. Bioanal. Chem. (2020) DOI: 10.1007/s00216-019-02304-0

Christina R. Ferreira, Alan K. Jarmusch, Clint M. Alfaro, and R. Graham Cooks “Ambient Lipidomic Analysis of Single Mammalian Oocytes and Preimplantation Embyros Using Desorption Electrospray Ionization (DESI) Mass Spectrometry.” in Single Cell Metabolism: Methods and Protocols (2020) DOI: 10.1007/978-1-4939-9831-9_13


Meng Wang, Xiao-Fei Gao, Rui Su, Peng He, Yuan-Yuan Cheng, Ke Li, Dongbo Mi, Xiaoping Zhang, Xinglei Zhang, Huanwen Chen, and R. Graham Cooks "Abundant Production of Reactive Water Radical Cations under Ambient Conditions" CCS Chem (2021) DOI:10.31635/ccschem.021.202101427

Kai-Hung Huang, Jyotirmoy Ghosh, Shiqing Xu, and R. Graham Cooks "Late-Stage Functionalization and Characterization of Drugs by High-Throughput Desorption Electrospray Ionization Mass Spectrometry" ChemPlusChem (2021) DOI:10.1002/cplu.202100449

L. Edwin Gonzalez, Lucas J. Szalwinski, Brett M. Marsh, J. Mitchell Wells, and R. Graham Cooks “Immediate and sensitive detection of sporulated Bacillus subtilis by microwave release and tandem mass spectrometry of dipicolinic acid” Analyst (2021) DOI:10.1039/D1AN01796A

Nicolás M. Morato, MyPhuong T. Le, Dylan T. Holden, and R. Graham Cooks “Automated High-Throughput System Combining Small-Scale Synthesis with Bioassays and Reaction Screening” SLAS Technology (2021) DOI:10.1177/24726303211047839

Lucas J. Szalwinski, Yanyang Hu, Nicolás M. Morato, R. Graham Cooks, and Gert IJ. Salentijn “Novel Ion Trap Scan Modes to Develop Criteria for On-Site Detection of Sulfonamide Antibiotics” Anal. Chem. (2021) DOI:10.1021/acs.analchem.1c02790

Lingqi Qiu, Zhenwei Wei, Honggang Nie, R. Graham Cooks “Reaction Acceleration Promoted by Partial Solvation at the Gas/Solution Interface” ChemPlusChem (2021)DOI: 10.1002/cplu.202100373

Rong Chen, Hannah Marie Brown and R. Graham Cooks “Metabolic profiles of human brain parenchyma and glioma for rapid tissue diagnosis by targeted desorption electrospray ionization mass spectrometry ”Anal. Bioanal. Chem. (2021)DOI: 10.1007/s00216-021-03593-0

MyPhuong T. Le, Nicolás M. Morato, Andreas Kaerner, Christopher J. Welch, and R. Graham Cooks “Fragmentation of Polyfunctional Compounds Recorded Using Automated High-Throughput Desorption Electrospray Ionization” J. Am. Soc. Mass Spectrom. (2021) DOI: 10.1021/jasms.1c00176

Robert L. Schrader, Brett M. Marsh, and R. Graham Cooks “Atmospheric Pressure Drift Tube Ion Mobility Spectrometry Coupled with Two-Dimensional Tandem Mass Spectrometry” J. Am. Soc. Mass Spectrom. (2021) DOI: 10.1021/jasms.1c00180

Madison E. Edwards, César A. Marasco Jr, Tracey B. Schock, Tiago J.P. Sobreira, Christina R. Ferreira, R. Graham Cooks “Exploratory analysis using MRM profiling mass spectrometry of a candidate metabolomics sample for testing system suitability” Int. J. Mass Spectrom. (2021) DOI: 10.1016/j.ijms.2021.116663

Yangjie Li, Kai-Hung Huang, Nicolás M. Morato and R. Graham Cooks “Glass surface as strong base, ‘green’ heterogeneous catalyst and degradation reagent” Chem. Sci. (2021) DOI: 10.1039/D1SC02708E

Brett M. Marsh, Saquib Rahman, Victoria M. Benkowski, Shane Tichy, and R. Graham Cooks “Space Charge Compensation in Air by Counterion Flow in 3D Printed Electrode Structure” Int. J. Mass Spectrom. (2021) DOI: 10.1016/j.ijms.2021.116637

Nicolás M.Morato, R. Graham Cooks “Inter-platform assessment of performance of high-throughputdesorption electrospray ionization mass spectrometry” Talanta Open (2021) DOI: 10.1016/j.talo.2021.100046

Zhuoer Xie, Christina R. Ferreira, Alessandra A. Virequ, and R. Graham Cooks “Multiple Reaction Monitoring Profiling (MRM Profiling): Small Molecule Exploratory Analysis Guided by Chemical Functionality” Chemistry and Physics of Lipids (2021) DOI: 10.1016/j.chemphyslip.2021.105048

Hannah Marie Brown, Clint M. Alfaro, Valentina Pirro, Mahua Dey, Eyas M. Hattab, Aaron A. Cohen-Gadol, and R. Graham Cooks “Intraoperative Mass Spectrometry Platform for IDH Mutation Status Prediction, Glioma Diagnosis, and Estimation of Tumor Cell Infiltration” Journal of Applied Laboratory Medicine (2021) DOI: 10.1093/jalm/jfaa233

Lucas J. Szalwinski and R. Graham Cooks “Complex Mixture Analysis by Two-Dimensional Mass Spectrometry using a Miniature Ion Trap” Talanta Open (2021) DOI: 10.1016/j.talo.2020.100028


L. Edwin Gonzalez, Lucas J. Szalwinski, Thomas C. Sams, Eric T. Dziekonski, and R. Graham Cooks "Metabolomic and Lipidomic Profiling of Bacillus Using Two-Dimensional Tandem Mass Spectrometry" Anal. Chem. (2022) DOI:10.1021/acs.analchem.2c03961

Nicolás M. Morato, Hannah Marie Brown, Diogo Garcia, Erik H. Middlebrooks, Mark Jentoft, Kaisorn Chaichana, Alfredo Quiñones-Hinojosa, and R. Graham Cooks "High-throughput analysis of tissue microarrays using automated desorption electrospray ionization mass spectrometry" Sci. Rep. (2022) DOI:10.1038/s41598-022-22924-4

Jyotirmoy Ghosh, Joshua Mendoza, and R Graham Cooks "Accelerated and Concerted Aza-Michael Addition and SuFEx Reaction in Microdroplets in Unitary and High-Throughput Formats" Angew. Chem. (2022) DOI:10.1002/anie.202214090

Dylan T Holden, Nicolás M Morato, and R. Graham Cooks "Aqueous microdroplets enable abiotic synthesis and chain extension of unique peptide isomers from free amino acids" Proc. Natl. Acad. Sci. U.S.A. (2022) DOI: 10.1073/pnas.2212642119

Jyotirmoy Ghosh and R. Graham Cooks "Facile Synthesis of Triazoles using Electrospray-Deposited Copper Nanomaterials to Catalyze Azide-Alkyne Cycloaddition (AAC) Click Reactions" ChemPlusChem (2022) DOI:10.1002/cplu.202200252

Lingqi Qiu and R. Graham Cooks "Simultaneous and Spontaneous Oxidation and Reduction in Microdroplets by the Water Radical Cation/Anion Pair" Angew. Chem. (2022) DOI:10.1002/anie.202210765

Lingqi Qiu, Nicolás M Morato, Kai-Hung Huang, and R. Graham Cooks "Spontaneous Water Radical Cation Oxidation at Double Bonds in Microdroplets" Front. Chem. (2022) DOI:10.3389/fchem.2022.903774

Lingqi Qiu, Michael D. Psimos, and R. Graham Cooks "Spontaneous Oxidation of Aromatic Sulfones to Sulfonic Acids in Microdroplets" JASMS (2022) DOI:10.1021/jasms.2c00029

Sangeeta Pandey, Yanyang Hu, Lane R. Bushman, Jose Castillo‑Mancilla, Peter L. Anderson, and R. Graham Cooks "Miniature mass spectrometer–based point‑of‑care assay for cabotegravir and rilpivirine in whole blood" Anal. Bioanal. Chem. (2022) DOI:10.1007/s00216-022-03954-3

Lucas Szalwinski, L. Edwin Gonzalez, Nicolás M Morato, Brett Marsch, and R. Graham Cooks"Bacterial Growth Monitored by Two-Dimensional Tandem Mass Spectrometry" Analyst (2022) DOI:10.1039/D1AN01901E

Xingshuo Chen, Zhenwei Wei, Kai-Hung Huang, Mycah Uehling, Michael Wleklinski, Shane Krska, Alexey A. Makarov, Timothy Nowak, and R Graham Cooks "Pd Reaction Intermediates in Suzuki-Miyaura Cross-coupling Characterized by Mass Spectrometry" ChemPlusChem (2022) DOI:10.1002/cplu.202100545

Samadhi C. Kulathunga, Nicolás M. Morato, Qing Zhou, R. Graham Cooks and, Andrew D. Mesecar "Desorption Electrospray Ionization Mass Spectrometry Assay for Label-Free Characterization of SULT2B1b Enzyme Kinetics" ChemMedChem (2022) DOI:10.1002/cmdc.202200043


MyPhuong T. Le, Dylan T. Holden, Jeremy M. Manheim, Eric T. Dziekonski, Kiran Iyer, R Graham Cooks "Two-dimensional Tandem Mass Spectrometry for Biopolymer Structural Analysis" Angewandte Chemie (2023)  DOI:10.1002/ange.202315904

Yanyang Hu, Eric T. Dziekonski, Donna M. Wang, L. Edwin Gonzalez, R Graham Cooks "Rapid Identification of Phenolics in Mixtures by Two-Dimensional Tandem Mass Spectrometry with Microdroplet Accelerated Derivatization Reactions" Analysis & Sensing (2023)  DOI:10.1002/anse.202300081

L. Edwin Gonzalez, Dalton T. Snyder, Harman Casey, Yanyang Hu, Donna M. Wang, Megan Guetzloff, Nicole Huckaby, Eric T. Dziekonski, J. Mitchell Wells, and R. Graham Cooks "Machine-Learning Classification of Bacteria Using Two-Dimensional Tandem Mass Spectrometry" Analyctical Chem (2023) DOI:10.1021/acs.analchem.3c04016

Lingqi Qiu, Mousumi Saha, Stefan Kraft, Eric T. Dziekonski, Christopher J. Welch, Yumin Dai, Andreas Kaerner, R. Graham Cooks "Quantitative Determination of Water in Organic Liquids by Ambient Mass Spectrometry" Angew Chem (2023) DOI:10.1002/ange.202310884

Nicolás M. Morato and R. Graham Cooks"Desorption Electrospray Ionization Mass Spectrometry: 20 Years" Acc Chem Res (2023) DOI:10.1021/acs.accounts.3c00382

Eric T. Dziekonski, Gregory S. Eakins, R. Graham Cooks "Enabling one- and two-dimensional mass spectrometry in a linear quadrupole ion trap" Int J Mass Spectrom (2023) DOI:10.1016/j.ijms.2023.117099

R. Graham Cooks "Ion traps and Piero Traldi: A brief appreciation" Mass Spectrom Rev (2023) DOI:10.1002/mas.21753

Kai-Hung Huang, Nicolás M. Morato, Yunfei Feng, R. Graham Cooks "High-throughput Diversification of Complex Bioactive Molecules by Accelerated Synthesis in Microdroplets" Angew Chem Int Ed (2023) DOI:10.1002/anie.202300956

R. Graham Cooks, Yunfei Feng, Kai-Hung Huang, Nicolás M. Morato, Lingqi Qiu "Re-Imagining Drug Discovery using Mass Spectrometry" Isr. J. Chem. (2023) DOI:10.1002/ijch.202300034 [pdf]

Eric T. Dziekonski, Thomas C. Sams, Lucas J. Szalwinski, L. Edwin Gonzalez, and R. Graham Cooks "Automated desorption electrospray ionization two-dimensional tandem mass spectrometry: Instrumentation and software for high throughput analysis" Int J Mass Spectrom (2023) DOI:10.1016/j.ijms.2023.117023

Sangeeta PandeyYanyang HuPeter L. AndersonJennifer J. Kiser and R. Graham Cooks "Miniature mass spectrometer-based point-of-care assay for measuring phosphatidylethanol in blood" Analyst (2023) DOI:10.1039/D3AN00098B

Jyotirmoy Ghosh, R. Graham Cooks "Mass spectrometry in materials synthesis" Trends in Analytical Chemistry (2023) DOI:10.1016/j.trac.2023.117010


Lingqi Qiu, R. Graham Cooks "Oxazolone mediated peptide chain extension and homochirality in aqueous microdroplets" Proc. Natl. Acad. Sci. (2024) DOI:10.1073/pnas.2309360120